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The S&P 500 was down 0.3% in midday trading to 2,715.39.
The Dow Jones Industrial Average declined 0.1% to 24,256.48.
The Nasdaq was down 0.9% to 7,494.77.
The yield on a 10-year Treasury bond dove 1.5% to 2.84%.
The price of gold was 0.3% lower to $1,256.
Edwards Lifesciences Corp. (NYSE: EW) in Irvine was down 3.2% to $145.44 and a $30.7 billion market cap. It makes heart valves.
ICU Medical Inc. (Nasdaq: ICUI) in San Clemente was down 3.2% to $288.75 and a $5.9 billion market cap. It makes infusion therapy devices.
Spectrum Pharmaceuticals Inc. (Nasdaq: SPPI) in Irvine was down 3.1% to $21.08 and a $2.2 billion market cap. It makes drugs to treat cancer and blood disease.