Big Health is getting more validation for its digital therapeutics.
The company’s technology in March was featured in the Journal of the American Medical Association (JAMA), marking the 100th peer-reviewed paper publication for the mental health-focused company.
It’s the latest milestone for Big Health since it received FDA clearance for its self-guided cognitive behavioral therapy apps SleepioRx and Daylight Rx, designed to treat insomnia and generalized anxiety disorders, respectively.
“Many times, when you’re building an innovative startup company, you’re alone with long nights trying to do something kind of impossible that lots of people have asked if it’s going to work or not,” former Executive Chairman Arun Gupta told the Business Journal last September. “You’re short on these sorts of recognition.”
Gupta was honored at the Business Journal’s Innovator of the Year Awards last year for steering the company—which offers six digital therapeutics in total—achieve clearance so doctors can prescribe them as treatments to patients.
He was also included in the Business Journal’s annual OC50 list with this year’s theme being rising entrepreneurs.
Big Health scored another large win at the end of last year when it was announced that prescription digital mental health treatments such as SleepioRx and DaylightRx would be covered by Medicare.
The Centers for Medicare & Medicaid Services (CMS) finalized three new codes in its 2025 physician fee schedule, which went into effect in January.
Big Health said that it anticipates these codes will be adopted by commercial insurance plans, “paving the way for broader coverage for Americans.”
Gupta served as interim chief executive of Big Health until the company recruited a permanent CEO, Yael Berman, last April.
This year, he retired as executive chairman.
While still a major investor in Big Health, Gupta stepped down to accept the same role at Parallel Systems, according to a spokesperson. Parallel Systems was co-founded by Matt Soule, a former engineer for SpaceX. The Los Angeles-based startup is developing what it claims is the world’s first self-driving electric-powered rail car to help reduce the need for trucks.
It launched its commercial pilot in partnership with Genesee & Wyoming Inc. after raising a $38 million Series B round.
“I’m having fun working on this mission and technology with a world class founder, Matt Soule,” Gupta wrote in a recent LinkedIn post.
Prior to Big Health, Gupta had a long track record of running startups and founded Quartet Health, where he raised hundreds of millions in capital by providing insurers and health systems with a way to enhance collaboration between physical and mental health providers.
