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OC500 2025: BENJAMIN ESQUE  

BENJAMIN ESQUE  

CEO  

CORSTASIS THERAPEUTICS INC.  

 

WHY: Invested money and has raised roughly $20M to create a formulation for Enbumyst, a nasal spray to remove excess body fluid associated with congestive heart failure. Former executive at Edwards Lifesciences who began his 20-year career in interventional cardiology at Cordis.  

IN THE NEWS: FDA accepted company’s New Drug Application for Enbumyst in January. The company is aiming to be launch-ready about a month after the FDA has completed its review process of the application.   

NOTABLE: Company took inspiration from Narcan for its own nasal spray. Advisory board includes Roger Crystal, founder of Opiant Pharmaceuticals Inc., which invented Narcan for reversing opioid overdoses. 

QUOTABLE: “What once started as a crazy idea is now a product that has been tested effectively in humans.”   

 

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