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OC500 2025: MIKE MUSSALLEM  

MIKE MUSSALLEM  

FORMER CHAIRMAN/CEO 

EDWARDS LIFESCIENCES CORP. 

 

WHY: First and longtime CEO of Orange County’s largest medtech employer, with about 4K workers and 15K worldwide. The Irvine-based heart valve maker is OC’s most valuable public company in the healthcare sector, sporting a $45B market cap as of October.  

IN THE NEWS: This year, co-founded alongside his wife Linda a new nonprofit called the Mussallem CHD Alliance to focus on congenital heart defects. Recently revealed he has Lou Gherig’s disease.

NOTABLE: Named Businessperson of the Year by the Business Journal in the health sector in 2023.  

QUOTABLE: “I’m proud of Edwards’ continued dedication in providing innovative technologies and solutions for patients fighting cardiovascular disease and also restoring the critically ill to health.”   

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