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OC500 2025: ERIC LEFKOFSKY 

ERIC LEFKOFSKY 

FOUNDER/CHAIRMAN/CEO 

TEMPUS AI INC 

 

WHY: Started in 2015 Tempus AI, a tech co. advancing in precision medicine by applying AI in healthcare. Best known as co-founder and chairman of Chicago-based e-commerce marketplace Groupon Inc. 

IN THE NEWS: Says Tempus’ acquisition of Ambry from Konica Minolta in late 2024 broadens the company’s testing portfolio, expands disease coverage and enhances types of products it offers to biotech and pharmaceutical firms. Also notes Tempus’ growth was “north of 25% a year and it generates meaningful EBITDA and cash flow” when acquisition was announced.  

NOTABLE: Established Lefkofsky Family Foundation, a private charitable foundation, with his wife in 2006. Trustee of Steppenwolf Theatre Company, School of the Art Institute of Chicago, Lurie Children’s Hospital of Chicago and World Business Chicago. Author of “Accelerated Disruption: Understanding the True Speed of Innovation.”  

QUOTABLE: “Businesses are best when there is some personal motivation, when you are trying to solve a problem that is personal to you.” — Eric Lefkofsky’s website 

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