The Nasdaq was down 0.04% to 3,135 in midday trading Friday, while the Dow Jones Industrial Average fell 0.06% to 13,285.
The S&P 500 rose 0.28% to 1,436.
The yield on a 10-year treasury bond was off 1.61% to 1.65%.
The price of gold was up 1.82% to $1,739 per ounce.
Shares of Tustin-based drug developer Peregrine Pharmaceuticals Inc. surged about 50% to nearly $5 for a recent market value of $355 million. Peregrine revealed results on its experimental drug bavituximab, which showed lung cancer patients living longer when treated with a combination of its drug and chemotherapy.
Shares of Irvine-based Endologix Inc. rose about 7% to $13 after the medical device maker received European regulatory approval for its Nellix Endovascular Aneurysm sealing device. Endologix had a recent market value of $777 million.
Huntington Beach-based Quiksilver Inc. jumped 21% to nearly $4, a day after the action sports retailer and apparel maker reported better-than-expected results for the July quarter and sales growth for core brands Quiksilver, Roxy and DC Shoes. Quiksilver had a recent market value of $608 million.