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The S&P 500 was down 0.3% in midday trading to 2,897.06.
The Dow Jones Industrial Average declined 0.2% to 26,107.33.
The Nasdaq fell 0.9% to 7,935.07.
The yield on a 10-year Treasury bond was unchanged at 2.99%.
The price of gold fell 0.4% to $1,206.
Avid Bioservices Inc. (Nasdaq: CDMO) fell 4.6% to $6.83 and a $383 million market cap. Shares of Avid, a Tustin-based contract drug manufacturer, have more than doubled since a 52-week low in April.
Tilly’s Inc. (NYSE: TLYS) in Irvine was down 3.1% to $17.99 to a $529 million market cap. Shares of the fashion retailer shares have declined about 29% since Sept. 4 when the company said some shareholders, including its founders, planned to sell 8.1 million common shares.