The S&P 500 was flat in midday trading at 2,722.11.
The Dow Jones Industrial Average declined 0.2% to 24,729.07.
The Nasdaq fell 0.1% to 7,390.30.
The yield on a 10-year Treasury bond rose 0.4% to 3.11%.
The price of gold was down 0.2% to $1,290.
Spectrum Pharmaceuticals Inc. (Nasdaq: SPPI) in Irvine was up 13% to $20.18 and a $2.1 billion market cap. Phase 3 trial results of one of its drug candidates may establish it as a “possible supportive care treatment option” the lead investigator said. Spectrum makes drugs to treat cancer and blood disease.
Tilly’s Inc. (NYSE: TLYS) in Irvine was up 4.7% to $11.94 and a $348 million market cap. The youth fashion retailer said it will report results May 30.