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The S&P 500 was down 0.2% in midday trading to 2,894.46.
The Dow Jones Industrial Average dropped 0.4% to 25,907.42.
The Nasdaq rose 0.1% to 8,099.45.
The yield on a 10-year Treasury bond declined 0.7% to 2.84%.
The price of gold was up 0.3% to $1,205.
Spectrum Pharmaceuticals Inc. (Nasdaq: SPPI) dropped 4.9% to $21.52 and a $2.3 billion market cap. Shares of Spectrum, a maker of drugs for cancer and blood diseases, have more than doubled in the past year.
Youth retailer Tilly’s Inc. (Nasdaq: TLYS) in Huntington Beach was up 19.2% to $24.58 and a market cap of $725 million. Shares have risen since the retail chain reported fiscal second-quarter revenue and profit that topped the average estimates of three analysts. Tilly’s credits its sales increase to back-to-school spending.