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The S&P 500 was down 0.2% in midday trading to 2,628.67.
The Dow Jones Industrial Average fell 0.3% to 23,955.53.
The Nasdaq declined 0.3% to 6,990.15.
The yield on a 10-year Treasury bond jumped 1.2% to 3.02%.
The price of gold was 0.7% lower at $1,323.
Edwards Lifesciences Corp. (NYSE: EW) in Irvine was down 4% to $129 and a $27 billion market cap. The heart valve maker, Orange County’s largest public company, missed Wall Street expectations on quarterly revenue.
Cryoport Inc. (Nasdaq: CYRX) in Irvine was up 9.8% to $7.37 and a $203 million market cap. The company, which cryogenically ships products globally for life sciences companies, plans to report quarterly results next week.
Tri Pointe Group Inc. (NYSE: TPH) in Irvine was up 2% to $16.60 and a $2.5 billion market cap. The largest home builder based in Orange County beat Wall Street expectations on revenue and earnings per share.