The S&P 500 was down 0.2% in midday trading to 2,651.21.
The Dow Jones Industrial Average declined 0.5% to 24,282.73.
The Nasdaq was flat at 7,098.82.
The yield on a 10-year Treasury bond fell 0.2% to 2.79%.
The price of gold was 1% higher to $1,360.
Spectrum Pharmaceuticals Inc. (Nasdaq: SPPI) in Irvine was up 6% to $22.05 and a $2.3 billion market cap. Shares in the developer of drugs to treat cancer and blood diseases closed up 40% yesterday after it reported positive results of a Phase 2 study of a drug being tested for treatment of nonsmall-cell lung cancer.
ChromaDex Corp. (Nasdaq: CDXC) in Irvine was up 4% to $4.41 and a $242 million market cap. It makes nutritional products and ingredients.