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The S&P 500 was down 0.1% in midday trading to 2,582.37.
The Dow Jones Industrial Average fell 0.4% to 23,372.99.
The Nasdaq rose 0.7% to 6,794.13.
The yield on a 10-year Treasury bond dropped 0.8% to 2.34%.
The price of gold jumped 1.3% to $1,295.
Spectrum Pharmaceuticals Inc. (Nasdaq: SPPI) in Irvine was down 7.3% to $19.22 and a $1.9 billion market cap on moderate volume. The company develops drugs to treat blood diseases and cancer.
ChromaDex Corp. (Nasdaq: CDXC) in Irvine was up 5.9% to $7.03 and a $339 million market cap. The maker of ingredients was scheduled to close a $23 million private placement today and its shares are up about 28% on the week.
Tilly’s Inc. (NYSE: TLYS) in Irvine was up 7.1% and a $383 million market cap on moderate volume. It runs a chain of youth fashion stores.