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The S&P 500 was down 0.2% in midday trading to 2,579.37.
The Dow Jones Industrial Average fell 0.2% to 23,405.61.
The NASDAQ ticked down 0.1% to 6,742.79.
The yield on a 10-year Treasury bond jumped 3% to 2.40%.
The price of gold declined 0.9% to $1,276.
ICU Medical Inc. (Nasdaq: ICUI) in San Clemente was up 9% to $203.05 and a $4 billion market cap. The infusion therapy products maker increased guidance for this year and initial 2018 guidance about 25% higher than 2017’s range.
ChromaDex Corp. (Nasdaq: CDXC) in Irvine was up 9.4% to $5.35 and a $257 million market cap. The ingredients maker reported sales up 55% in its most recent quarter.
Alteryx Inc. (NYSE: AYX) in Irvine was up 15% to $25.21 and a $1.5 billion market cap. The data analytics software maker beat Wall Street expectations in its most recent quarter.