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The S&P 500 was down 0.4% in midday trading to 2,391.27.
The Dow Jones Industrial Average was down 0.2% to 20,895.24.
The NASDAQ was down 0.3% to 6,109.58.
The yield on a 10-year Treasury bond was down 0.6% to 2.40%.
The price of gold rose 0.4% to $1,224.
ICU Medical Inc. in San Clemente was up 5% to $170.90 and a $3.4 billion market cap. The infusion products maker had net income of $56 million on revenue of $248 million in its most recent quarter.
CryoPort Inc. in Irvine was up 9% to $3.04 and a $73 million market cap on average volume. Shares are up about 60% since the cryogenic logistics service provider for life sciences companies reported a 74% year-over-year revenue increase in its most recent quarter.