The S&P 500 was down 0.3% to 1,954.27.
The Dow Jones Industrial Average was down 0.2% to 16,384.72.
The Nasdaq was down 0.3% to 4,808.57.
The yield on a 10-year Treasury bond was up 0.1% to 2.18%.
The price of gold was up 0.4% to $1,108.
Santa Ana-based BioLarge Inc. was up 18.3% to 71 cents and a $60 million market cap. The iodine-filtration system maker had by midday traded about 10 times the number of shares in its 90-day average.