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Irvine-based Allergan Inc. has filed papers with state officials saying it will lay off 129 employees.

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The layoffs are effective Oct. 31, according to a Worker Adjustment and Retraining Notification notice filed with the state Employment Development Department.

Allergan has said it will cut some 1,500 workers companywide this year as part of a restructuring it is undergoing as it attempts to fight off a hostile takeover bid from Canadian drug maker Valeant Pharmaceuticals International Inc. and activist investor Bill Ackman’s Pershing Square Capital Management LP.