The S&P 500 was down 0.1% in midday trading to 2,462.72.

The Dow Jones Industrial Average fell 0.1% to 21,983.18.

The NASDAQ declined 0.1% to 6,333.85.

The yield on a 10-year Treasury bond was up 0.7% to 2.25%.

The price of gold was down 0.8% to $1,280.

HEALTHCARE

Tustin’s Peregrine Pharmaceuticals Inc. (Nasdaq: PPHM) declined 5.9% to $3.20 and a $144 million market cap. Ronin Trading and SW Investment Management, which combine to own 8.8% of shares, yesterday said in a statement that management and the board of directors have “unjustifiable” compensation. Shares of the company, which last week said it would lay off 20% of its workforce to cut costs, have fallen 45% from its 52-week high in July.

Auxilio Inc. (NYSE: AUXO) rose 6.4% to $3.49 and a $33 million market cap. Shares are still down 24% since Aug. 10, when the Mission Viejo manager of document workflow reported second-quarter results.