The S&P 500 was down 0.5% in midday trading to 2,073.35.
The Dow Jones Industrial Average was down 0.8% to 17,785.87.
The NASDAQ was down 0.4% to 4,788.81.
The yield on a 10-year Treasury bond was down 1.9% to 1.73%.
The price of gold was up 0.9% to $1,276.
Mission Viejo-based Ensign Group Inc. was up 4% to $22.42 and a $1.2 billion market cap. The healthcare facility operator met analysts’ profit forecasts and increased its full-year guidance in its most recent quarterly report.
Tustin-based Peregrine Pharmaceuticals Inc. was up 13% to 38 cents and an $88 million market cap on above-average trading volume for the company, which is developing a treatment for cancer.