The S&P 500 fell 0.10% to 1,836.06 in afternoon trading Wednesday.
The Dow Jones Industrial average slipped 0.52% to 16,445.59, while the Nasdaq rose 0.25% to 4,163.54.
The yield on a 10-year Treasury bond was up 2.18% to 3.00%.
The price of gold was down 0.56% to $1,222.70 per ounce.
Irvine-based drug maker Allergan Inc. rose about 2% to $115.02 for a market value of $34.18 billion. The company said Tuesday it closed on a previously announced, $65 million licensing agreement with South Korea-based Medytox Inc. to develop some of Medytox's neurotixin product.
Irvine-based patient monitor maker Masimo Corp. was up about 3% to $31.21 for a market value of $1.76 billion. The company announced the opening of offices in India.