The S&P 500 slipped 0.76% to 1,756.96 in afternoon trading Thursday.
The Dow Jones Industrial Average was down 0.51% to 15,667, while the Nasdaq was off 1.29% to 3,881.17.
The yield on a 10-year Treasury bond fell 1.10% to 2.61%.
The price of gold slipped 0.69% to $1,308.70 per ounce.
Irvine heart valve maker Edwards Lifesciences Corp. was up about 2% to $63.85 for a market value of $7.09 billion.
Aliso Viejo-based chipmaker Microsemi Corp. was off about 2% to $24.59 for a market value of $2.29 billion. The company is expected to report its fourth-quarter and full-year results after market close Thursday.