Shares of Irvine-based heart valve maker Edwards Lifesciences Corp. fell after some analysts expressed concerns over the company's gain in sales of transcatheter valves during the fourth quarter.

Edwards was down about 5% in afternoon trading Tuesday to a market value of $10.2 billion.

The stock-up, which led to a 73% gain in transcatheter valves during the fourth quarter to $161 million, could cause a slowdown of sales in the second half of this year, Wunderlich Securities analyst Greg Simpson wrote in a note.

The fall comes a day after Edwards announced better-than-expected results for the fourth quarter after the market's close on Monday.

Edwards posted a profit of $106 million before charges, above analysts’ forecasts of $90.7 million.

Edwards’ net profit came in at $91.1 million, up 44% from the same period in 2011.

Fourth-quarter revenue rose 19% to $510.5 million. Analysts had expected revenue of $500.1 million.

Edwards reported $293 million in net profit for 2012, up about 24% from the year earlier. Revenue was $1.9 billion, a gain of about 13% from 2011.

The device maker also outlined its expectations for 2013.

It could see a profit of $378.1 million to $389.9 million. Analysts are expecting 2013 profit of $385.2 million.

Edwards said it continued to expect full-year 2013 sales of $2.1 billion to $2.2 billion. Wall Street forecasts the device maker’s sales at $2.14 billion.